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Mesotheliomas frequently harbor loss of the chromosome 9p21.3 locus (CDKN2A–MTAP), associated with shorter overall survival due to loss of the tumor suppressor p16ink4A, an endogenous suppressor of cyclin-dependent kinase (CDK)4 and Cyclin-dependent kinase 6 (CDK6)
Fennell et al. 2022 The Lancet Oncology 23: 374-381
Genetic restoration of p16ink4A suppresses mesothelioma in preclinical models, underpinning the rationale for…