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Most antibodies in the body belong to the IgA class (3, 4, 5, 6, 7). IgA is the primary secreted antibody (1). IgA accumulates mutations throughout an individual's lifetime (1). Mutations in IgA are often linked to microbial induction (1). Early-life diet can independently influence IgA induction, its repertoire, and mutation diversity (1)
In both germ-free and colonized mice, different diets were tested (1). Dietary lipopolysaccharide contamination activated Toll-like receptor (TLR) 4 signaling (1). TLR 4 signaling enhanced germinal center activity in the intestinal immune system (1). Lipopolysaccharide's impact on mucosal immune induction was observed only when delivered in colloidal liposomes (1). Delivery method of lipopolysaccharide is crucial for its effectiveness (1)
Plas…