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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Butyrate / Butyric acid & HT-29 cells

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Growth Inhibition and Cell Cycle Arrest

Butyrate / Butyric acid significantly inhibits the proliferation of HT-29 colon cancer cells, primarily by arresting the cell cycle in the G0/G1 phase. This alters the expression of key cell cycle proteins, which is considered an essential component of butyrate's anticancer effect.
Coradini et al. 2000 Cell Prolif 33(3): 139-46
Siavoshian et al. 2000 Gut 46(4): 507-14
Rouet-Benzineb et al. 2004 Journal of Biological Chemistry 279(16): 16495-16502

Induction of Differentiation

Butyrate rapidly induces morphological changes and differentiation in HT-29 cells. The process leads to features that are typical of normal [colonoc…

References (Sources)

Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression
Siavoshian et al. 2000 Gut 46(4): 507-14
Butyrate modulates intestinal epithelial cell-mediated neutrophil migration
Böcker et al. 2003 Clin Exp Immunol 131(1): 53-60
Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells
Barnard & Warwick 1993 Cell Growth Differ 4(6): 495-501
Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR-4 expression
Lee et al. 2005 Biochem Biophys Res Commun 337: 457–463
Leptin Counteracts Sodium Butyrate-induced Apoptosis in Human Colon Cancer HT-29 Cells via NF-κB Signaling
Rouet-Benzineb et al. 2004 Journal of Biological Chemistry 279(16): 16495-16502
Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells
Coradini et al. 2000 Cell Prolif 33(3): 139-46
The Stable Isotope-based Dynamic Metabolic Profile of Butyrate-induced HT29 Cell Differentiation
Boren et al. 2003 The Journal of Biological Chemistry 278(31): 28395-28402

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