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The clinical phase III trial, identified as EMR 062202-025, demonstrated that progression-free survival (PFS), overall response rate (ORR), and quality of life (QoL) were enhanced when cetuximab was combined with irinotecan as a second-line treatment for patients with RAS-wild type metastatic colorectal cancer (mCRC). This finding confirms that cetuximab-based therapy is appropriate for this patient group. It is noteworthy that nearly half of the patients in the irinotecan arm received cetuximab after the study, which may have obscured any potential overall survival benefit from the addition of cetuximab (2).
Cetuximab + Irinotecan & Colorectal Cancer (CRC) (EGFR m) demonstrates clinically significant activity. This effectiveness is observed whether [Cetuximab](brain://B3Ee5YdYy1e48mvlBcQ_kA/CetuximabColorec…