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Th1/Th2 immune balance was found to play a critical role in pregnancy.
Mei et al. 2021 Reprod Sci doi: 10.1007/s43032-021-00803
Specifically, Th1 cells infiltrated the decidua-regulated trophoblast invasion during the peri-implantation period by participating in tissue remodeling and angiogenesis [17].
Mei et al. 2021 Reprod Sci doi: 10.1007/s43032-021-00803
After the implantation, Th1 immunity was quickly shifted to Th2 immune response, which accommodated fetal and placental development [17].
Mei et al. 2021 Reprod Sci doi: 10.1007/s43032-021-00803
Th1 immunity dominated again at the maternal-fetal interface during …