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Propionic acid and butyric acid inhibit isoproterenol- and adenosine deaminase-stimulated lipolysis in primary rat adipocytes, even with a PDE3 inhibitor present. They also inhibit basal and insulin-stimulated de novo lipogenesis by increasing phosphorylation and inhibiting acetyl CoA carboxylase. SCFAs impact fat storage, mobilization, and glucose uptake, potentially leading to healthier adipocytes. This could improve energy metabolism, reducing c…