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It often becomes dysregulated in cancers. Hyperactivation of WNT signaling is common. Genetic alterations in the WNT pathway vary. They differ between cancers. This suggests cancer-specific mechanisms. These mechanisms drive WNT-related diseases.
WNT pathway disruption contributes to tumorigenesis. This occurs in different organs. WNT affects the tumor cell environment. It also impacts the immune microenvironment.
Other beta-catenin targets increased by AvrA included Bmi1 , a cancer stem cell marker, matrix metalloproteinase-7 , and [cyclin D1](brain://lCuiGVtp_UWU6vcHuXgjUQ/Ccnd1Cy…