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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Diarrhea-predominant Irritable Bowel Syndrome (IBS) (IBS-D) & Gut microbiota

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Reports have indicated an increased level of serine protease activity, possibly originating from bacteria samples recovered from IBS-D sufferers. Although not correlated with bowel movements or present in individuals with acute infectious diarrhea, serine protease activity in mice is associated with increased mucosal colonic permeability and heightened visceral hypersensitivity, symptoms that also occur in humans with IBS-D
Dunlop et al. 2006 Am J Gastroenterol 101(6): 128…

References (Sources)

A pilot study of fecal serine-protease activity: a pathophysiologic factor in diarrhea-predominant irritable bowel syndrome
Róka et al. 2007 Clin Gastroenterol Hepatol 5(5): 550-555
Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes
Dunlop et al. 2006 Am J Gastroenterol 101(6): 1288-1294
Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients
Schoepfer et al. 2008 Neurogastroenterol Motil 20(10): 1110-1118
Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification
Lyra et al. 2009 World J Gastroenterol 15(47):5936-45.
Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract
Barman et al. 2008 Infect Immun 76(3):907-915
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice
Annaházi et al. 2009 Pain 144(1-2>): 209-217
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Gecse et al. 2008 Gut 57(5): 591-599

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