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In a preclinical animal study, Sun et al. found that probiotic Clostridium butyricum administration could significantly alleviate cognitive deficits and attenuate microglia-mediated neuroinflammation and Aβ deposition, which acted via the regulation of the probiotic on gut microbiota and the level of the important metabolite [butyrate](brain://E42jsss5J0Kk0Df0jHlQLg/ButyrateButyricA…