Gut microbiota & Vaccination / Vaccines

For instance, rotaviruses, which are among the most common causes of diarrheal diseases in infants and young children, illustrate this issue. The rotavirus vaccine demonstrates up to 90% effectiveness in preventing the disease in high-income countries. However, its efficacy drops to 50–60% in African and South Asian countries. This discrepancy may be attributed to differing immune responses to the vaccine, potentially caused by variations in the microbiota compositions of children in these regions.
Ahmed et al. 2022 Vaccine 40: 3444-3451

Herd immunity protects against [infectious diseases](br…