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Circular RNAs (circRNAs) are a novel class of non-coding RNAs characterized by their varying sizes, cellular abundance, and biological functions. CircRNAs are covalently closed single-stranded RNAs without ends. Initially considered mere byproducts of abnormal splicing, they now have an essential biological role.
Circular RNAs (circRNAs) regulate gene expression, and inhibit protein activity, among other functions. Many Circular RNAs (circRNAs) are common and evolutionarily conserved across different species.
These single-stranded, covalently closed RNA molecules are highly stable due to their unique structure, which lacks the typical 5′ cap and 3′ poly-A tail found in linear RNAs. This stability makes circRNAs resistant to exonuclease degradation, allo…