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A non-nucleotide, small-molecule STING agonist is SR-717
SR-717 functions as a direct cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) mimetic that induces the same “closed” conformation of STING (Stimulator of interferon genes)
SR-717 displayed antitumor activity, promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissue…