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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Bacterial meningitis & Streptococcus pneumoniae

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Streptococcus pneumoniae is a leading cause of bacterial meningitis in children, in immunocompromised adults and in the elderly.
van de Beek et al. 2004 N. Engl. J. Med. 351: 1849–1859
Ostergaard et al. 2005 BMC Infect. Dis. 5: 93

Streptococcus pneumoniae activated nociceptors through its pore-forming toxin pneumolysin to release Calcitonin gene-related peptide (CGRP) from nerve terminals.
Pinho-Ribeiro et al. 2023 Nature 615: 472-481

Calcitonin gene-related peptide (CGRP) acted through [Receptor activity modifying pr…

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Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion
Pinho-Ribeiro et al. 2023 Nature 615: 472-481
Clinical features and prognostic factors in adults with bacterial meningitis
van de Beek et al. 2004 N. Engl. J. Med. 351: 1849–1859
Clinical presentation and prognostic factors of Streptococcus pneumoniae meningitis according to the focus of infection
Ostergaard et al. 2005 BMC Infect. Dis. 5: 93

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Bacterial meningitis & Streptococcus pneumoniae

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