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Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), and cyclic GMP-AMP synthase (cGAS), are the primary receptors triggering the expression of Interferons Type I (IFN Type I) upon sensing of PAMPs or DAMPs, respectively
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