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Mw: 270 kD
Clostridioides (Clostridium) difficile toxin B (TcdB) induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes.
Clostridioides (Clostridium) difficile toxin B (TcdB) stimulates the secretion of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) from neurons and pro-inflammatory cytokines from pericytes.
Manion et al. 2023 Nature …