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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Synbiotics & Type 2 diabetes (T2D)

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Systematic reviews and meta-analyses

According to a meta-analysis (CRD42017080071) of randomized controlled clinical trials, supplementation with synbiotics in individuals with diabetes mellitus has been shown to improve metabolic variables. However, the extent of this improvement is relatively small. Despite this, synbiotics could serve as a potential supplementary treatment for enhancing metabolic outcomes.
Bock et al. 2021 Diabetologia 64: 26-41

Randomized clinical trials (RCTs)

Akkermansia muciniphila + Anaerobutyricum hallii + Bifidobacterium longum infantis + Clostridium beijerinckii + Clostridium butyricum + Inulin-type fructans (ITF) / Inulin & Type 2 Diabetes (T2D)
[Akkermansia muciniph…

References (Sources)

Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus
Moroti et al. 2012 Lipids Health Dis 11: 29
Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
Mahboobi et al. 2018 Adv Pharm Bull 8(4): 565-574
Review
Effects of probiotics and synbiotics on obesity, insulin resistance syndrome, type 2 diabetes and non-alcoholic fatty liver disease: a review of human clinical trials
Sáez-Lara et al. 2016 Int J Mol Sci 17: 928
Review
Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation
Perraudeau et al. 2020 BMJ Open Diabet Res Care 8(1): e001319
Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective
Han & Lin 2014 World J Gastroenterol 20(47): 17737-45
Review
Probiotics, prebiotics, synbiotics, and FMT for glycemic control: A systematic review of clinical efficacy and mechanistic readouts in type 2 diabetes and related dysglycemia
Shalbaf et al. 2025 Metabol Open 28: 100419
Review
The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials
Paul et al. 2022 Pharmacol Res 185: 106520
Meta-Analysis
Review

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