Lectin complement pathway

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What Is the Lectin Complement Pathway?

The lectin complent pathway is one of three complement-activation pathways. It belongs to the innate immune system and is activated when pattern-recognition molecules bind characteristic sugars on microbial surfaces (1, 2, 3, 4, 5)

Recognition of Microbial Carbohydrates by MBL and Ficolins

The main recognition molecules are:

Mannose-binding lectin (MBL)

[Ficolins](brain://api.thebrain.com/wzsofVOsh4ANI-lTZFbXXQ/97wrR9Qx-E-BT5x_9yfalA/Ficolins…

References (Sources)

Janeway’s Immunobiology 10th
Murphy et al. 2022 W.W. Norton & Company ISBN 978-0-393-68093-5
Structural and functional overview of the lectin complement pathway: its molecular basis and physiological implication
Matsushita et al. 2013 Arch Immunol Ther Exp (Warsz) 61(4): 273-83
Review
The lectin pathway of complement and rheumatic heart disease
Beltrame et al. 2015 Front Pediatr 2: 148
Review
The Lectin Pathway of the Complement System-Activation, Regulation, Disease Connections and Interplay with Other (Proteolytic) Systems
Dobó et al. 2024 Int J Mol Sci 25(3): 1566
Review

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