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Genetic prediction analysis revealed that periodontitis is a risk factor for ulcerative colitis (UC). However, periodontitis was not identified as a risk factor for Crohn's disease (CD) or inflammatory bowel disease (IBD) in general. Conversely, Crohn's disease, rather than UC or IBD, was found to exacerbate periodontitis. These findings suggest a bidirectional relationship between these conditions, highlighting the existence of a mouth-gut axis. Specifically, Crohn's disease is a risk factor for periodontitis, while periodontitis contributes to the exacerbation of ulcerative colit…