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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Beta toxins (CPB)

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Beta-toxins (CPB) are virulence factors of Clostridium perfringens Type B and Clostridium perfringens Type C. This toxin causes severe necrohemorrhagic enteritis in humans and animals
Miclard et al. 2009 J Med Microbiol. 58(Pt 6): 826-828
Tarek et al. 2021 Toxins (Basel) 13(12): 893

Beta-toxin (CPB) is a small pore-forming toxin that primarily targets intestinal endothelial cells. Its mechanism of action includes:

Binding to the cell membrane receptor CD31 (PECAM-1)

Formation of oligomers on the cell surface

Formation of pores in the ce…

References (Sources)

Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model
Fernandez-Miyakawa et al. 2007 Infect Immun. 75(3): 1443-52
Cell-specific targeting by Clostridium perfringens β-toxin unraveled: the role of CD31 as the toxin receptor
Posthaus & Bruggisser 2020 bioRxiv 1: 787242
Clostridium perfringens beta-toxin binding to vascular endothelial cells in a human case of enteritis necroticans
Miclard et al. 2009 J Med Microbiol. 58(Pt 6): 826-828
Clostridium perfringens type C necrotic enteritis in pigs: diagnosis, pathogenesis, and prevention
Posthaus et al. 2020 J Vet Diagn Invest. 32(2): 203-212
Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Clostridium perfringens Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells
Tarek et al. 2021 Toxins (Basel) 13(12): 893

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