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The trehalose metabolism as part of the human diet could promote the occurrence of hypervirulent Clostridioides (Clostridium) difficile strains. However, it was shown that the trehalose metabolic pathway is conserved in several lineages of C. difficile strains and is therefore not limited to hypervirulent strains. Additional mechanisms could therefore underlie the observed association between trehalose metabolism and increased clinical mortality in Clostridioides difficile infection (CDI)
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