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NLR family CARD domain-containing (NLRC) proteins have one or two N-terminal CARD (Caspase Activation and Recruitment Domain) domains. These domains enable them to interact with other proteins that also contain CARD domains for downstream signaling.
However, it's worth noting that NLRC3 / NOD3 (NOD-like receptor family CARD Domain-Containing Protein 3) and NLRC5 (NOD-like receptor family CARD Domain-Containing Protein 5) have undefined N-terminal domains and are grouped in this s…