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The term Clostridiales Family XI. Incertae Sedis refers to a taxonomic group within the order Clostridiales that has not been definitively classified into a specific family, as indicated by the Latin term Incertae Sedis meaning "of uncertain placement.
A reduction in the abundance of Clostridiales Family XI. Incertae Sedis has been associated with an increased risk of Clostridioides difficile infections (CDI). These bacteria may play a protective role by maintaining microbial diversity and resisting colonization by pathogens such as C. difficile
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