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Overexpression of IRS2 at the gene or protein level is evident in many cancers and has been shown to cause tumorigenesis and increased metastasis in vivo (8-10)
Engelhard et al. 2020
IRS2 phosphorylated at Ser1100 is detectable in several cancers, and the resulting phosphopeptide (pIRS2 1097-1105)) is endogenously processed and presented by the MHC-I molecule HLA-A*0201 at levels allowing immune solid recognition (7 and unpublished)
[Engelhard et al…