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Systemic therapies are becoming part of the multimodal armamentarium when surgery alone will not confer improvements.
Spierenburg et al. 2022 Expert Opinion on Therapeutic Targets 26(4): 333-345
The CSF1-CSF1R axis is the principal drug target; however, the effect of CSF1R inhibition on angiogenesis and the role of macrophages, which are essential in the postoperative course, needs further elucidation.
[Spierenburg et al. 2022 E…