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On October 16, 2018, the U.S. Food and Drug Administration (FDA) approved talazoparib for patients with deleterious or suspected deleterious germline BRCA-mutated, HER2-negative locally advanced or metastatic breast cancer. Patients must be selected for therapy based on an FDA-approved companion diagnostic for talazoparib.
Talazoparib was associated with superior efficacy, favorable patient-reported outcomes (PROs), and lower health resource utilization (HRU) rate versus chemotherapy in advanced Breast Cancer / Mammacarcinoma (BRCA m). Toxicities were manageable with talazoparib dose modification and supportive care.
see also:
[PARPs (Poly(ADP-Ribose) Polymerases) Inhibitors & Breast Cancer / Mammac…