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Patients with acute myeloid leukaemia (AML) positive for internal tandem duplication (ITD) mutations of FLT3 have poor outcomes.
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations occur in approximately 30% of patients with acute myeloid leukaemia.
Patients with FLT3-ITD-mutated acute myeloid leukaemia, particularly those with a high allelic frequency, relapse quickly and have a shortened overall survival compared with patients who have the wild-type FLT3.
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