Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Ozanimod functions as a selective sphingosine-1-phosphate receptor modulator, specifically targeting S1P1 and S1P5 receptors. This selectivity is a key feature of the drug, as it allows for more targeted effects compared to earlier S1P receptor modulators.
Ozanimod binds to S1P1 receptors on lymphocytes, causing receptor internalization and degradation. This process effectively removes S1P1 receptors from the cell surface.
Without functional S1P1 receptors, lymphocytes lose their ability to respond to S1P gradients, which are crucial for their egress from lymphoid tissues.
As a result, lymphocytes become sequestered in lymphoid organs, leading to a significant reduction in circula…