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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Hypermethylated in Cancer 1 (HIC1)

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Hypermethylated in Cancer 1 (HIC1) is a tumor suppressor gene located on chromosome 17p13.3. It is frequently hypermethylated or deleted in various human tumors and is involved in a contiguous-gene syndrome known as Miller-Dieker syndrome
Pinte et al. 2004 J Biol Chem. 279(37): 38313-24
Annanya et al. 2024 Cureus 16(3): e56664

Hypermethylated in Cancer 1 (HIC1) encodes a protein that functions as a transcriptional repressor, containing five Krüppel-like C2H2 zinc fingers and an N-terminal dimerization and autonomous repression domain called BTB/POZ
Pinte et al. 2004 J Biol Chem. 279(37): 38313-24
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Computational Analysis of Single Nucleotide Polymorphisms in Human HIC1 Gene
Annanya et al. 2024 Cureus 16(3): e56664
The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties
Pinte et al. 2004 J Biol Chem. 279(37): 38313-24

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Hypermethylated in Cancer 1 (HIC1)

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