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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Clostridium perfringens Type B

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Clostridium perfringens Type B is a significant pathogen that affects livestock and poses challenges in veterinary medicine. This bacterium is known for its ability to produce multiple toxins, which contribute to its virulence and pathogenicity.

The bacterium is highly toxic and difficult to culture for vaccine production
Ashoori et al. 2024 bioRxiv https://doi.org/10.1101/2024.04.12.589226

Clostridium perfringens Type B is characterized by its ability to produce three main toxins:

Alfa toxin (CPA)

Beta toxins (CPB)

Epsilon-toxin (ETX)
These toxins play crucial roles in the pathogenesis of diseases caused by Clostridium perfringens Type B. The production of t…

References (Sources)

Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model
Fernandez-Miyakawa et al. 2007 Infect Immun. 75(3): 1443-52
Gut Microbiota in Multiple Sclerosis: Possible inﬂuence of immunomodulators.
Cantarel et al. 2015 J. Investig. Med. 63: 729–734
In Silico Vaccine Design: Targeting Highly Epitopic Regions of Clostridium perfringens Type D Epsilon Toxin and Clostridium novyi Type B Alpha Toxin for Optimal Immunogenicity
Ashoori et al. 2024 bioRxiv https://doi.org/10.1101/2024.04.12.589226
Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease
Rumah et al. 2013 PLoS ONE 8: e76359

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https://doi.org/10.1101/2024.04.12.589226