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Some Ly49 receptors have evolved to recognise specific viral proteins, for example Ly49H binds to murine cytomegalovirus (MCMV) glycoprotein m157. Mouse strains without Ly49H are more susceptible to MCMV infection. In addition these Ly49H positive NK cells have properties of MCMV specific memory NK cells and react better during secondary MCMV infections.
see also:
Group 1 ILCs (ILC1)
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