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Recent evidence suggests that the composition of gut microbiota may be linked to the development of Colorectal Cancer (CRC) in the context of probiotics. Modulating gut microbiota through the use of probiotics and prebiotics, whether used individually or together, could positively impact the interaction between the immune system and microbiota. This modulation may be beneficial in preventing inflammation and CRC. Some human studies have shown support for the beneficial effects of probiotics and prebiotics. Therefore, a comprehensive understanding is urgently needed to realize the clinical applications of probiotics and prebiotics in the prevention of CRC…