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As a key signaling molecule in the Brain-Gut-Microbiome-Axis / Gut-Brain Axis (MGBA), Tryptophan metabolites can regulate neuroinflammation, oxidative stress responses, and the abnormal aggregation of pathological proteins in the brain. This regulation occurs through circulatory immunity, neuroendocrine pathways, and the vagus nerve, affecting proteins such as beta-amyloid (Aβ) and alfa-synuclein (α-synuclein) (1, 2, 3, 4, 5, 6, 7).
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