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Several studies have reported roles for increased ROS and Mitochondrial permeability transition pore (mPTP) opening as triggers of autophagy. Opening of the Mitochondrial permeability transition pore (mPTP) results in swelling of the inner mitochondrial membrane with disruption of the cristae and subsequent rupture of the outer membrane. Opening of the Mitochondrial permeability transition pore (mPTP) has been implicated in the induction of autophagy and selective removal of damaged mitochondria by autophagosomes. A functional mPTP is also required for starvation-induced [mitochondria…