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In spite of the interest of targeting CB2r for pain, clinical trials evaluating CB2r agonist analgesic efficacy have currently failed.
The preferential involvement of CB2r in preventing the development of chronic pain could influence the failure of clinical trials designed for the treatment of already established pain syndromes.
see also:
Cannabinoid receptor agonists
Cannabinoid receptor 2 (CB2) & Central Nervous System (CNS)…